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The effect of proton pump inhibitorsPPIon the systemic exposure to the clopidogrel active metabolite following multiple doses of Plavix 75 mg evaluated in dedicated drug interaction studies is presented in Figure 1.

BMay be acceptableEither animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

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A randomizedplacebo-controlled trialCLARINETdid not demonstrate a clinical benefit of clopidogrel in neonates and infants with cyanotic congenital heart disease palliated with a systemic-to-pulmonary arterial shuntPossible factors contributing to this outcome were the dose of clopidogrelthe concomitant administration of aspirin and the late initiation of therapy following shunt palliationIt cannot be ruled out that a trial with a different design would demonstrate a clinical benefit in this patient population.

Diminished Antiplatelet Activity In Patients With Impaired CYP2C19 Function.

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hypersensitivity including rash, angioedema or hematologic reaction has been reported in patients receiving plavix, including patients with a history of hypersensitivity or hematologic reaction to other thienopyridines see contraindications and adverse reactions .